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Enantioselective Synthesis of 4-(Dimethylamino)pyridinesthrough a Chemical Oxidation-Enzymatic Reduction Sequence.Application in Asymmetric Catalysis
dc.contributor.author | Busto García, Benjamín Eduardo | |
dc.contributor.author | Gotor Fernández, Vicente | |
dc.contributor.author | Gotor Santamaría, Vicente Miguel | |
dc.date.accessioned | 2020-05-20T08:39:05Z | |
dc.date.available | 2020-05-20T08:39:05Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Advanced Synthesis and Catalysis, 348(18), p. 2626-2632 (2006); doi:10.1002/adsc.200600274 | |
dc.identifier.issn | 1615-4150 | |
dc.identifier.uri | http://hdl.handle.net/10651/54882 | |
dc.description.abstract | Enantiomerically pure 4-(dimethylamino)-3-(1-hydroxyalkyl)pyridines and 4-(dimethylamino)-3-[hydroxyACHTUNGTRENNUNG(phenyl)methyl]pyridine have been pre-pared through efficient chemoenzymatic routes. Forthis purpose different lipases and oxidoreductaseshave been tested in the preparation of opticallyactive 4-chloro derivatives and baker´s yeast wasfound to be an excellent catalyst for the bioreduc-tions of the corresponding ketones. Their applica-tions as enantioselective nucleophilic catalysts havebeen studied, important catalytic properties were ob-served in the stereoselective construction of quater-nary centers | spa |
dc.description.sponsorship | We thank Novo Nordisk Co. for the generous gift of theCAL-B (Novozyme 435) and Jlich Fine Chemicals for alco-hol dehydrogenases from Thermoanaerobacter species (T-ADH) and Lactobacillus brevis (LB-ADH). Financial sup-port of this work by the European Project EU-04-LSHB-2003–503017 is gratefully acknowledged. V.G.-F. thanksMEC for a personal grant (Juan de la Cierva Program). E.B.thanks MEC for a pre-doctoral fellowship | spa |
dc.format.extent | p. 2626-2632 | |
dc.language.iso | eng | spa |
dc.relation.ispartof | Advanced Synthesis and Catalysis, 348 | spa |
dc.rights | © 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim | |
dc.title | Enantioselective Synthesis of 4-(Dimethylamino)pyridinesthrough a Chemical Oxidation-Enzymatic Reduction Sequence.Application in Asymmetric Catalysis | spa |
dc.type | journal article | spa |
dc.identifier.doi | 10.1002/adsc.200600274 | |
dc.relation.projectID | EU-04-LSHB-2003–503017 | spa |
dc.relation.publisherversion | https://doi.org/10.1002/adsc.200600274 | spa |
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