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Enantioselective Synthesis of 4-(Dimethylamino)pyridinesthrough a Chemical Oxidation-Enzymatic Reduction Sequence.Application in Asymmetric Catalysis

dc.contributor.authorBusto García, Benjamín Eduardo 
dc.contributor.authorGotor Fernández, Vicente 
dc.contributor.authorGotor Santamaría, Vicente Miguel 
dc.date.accessioned2020-05-20T08:39:05Z
dc.date.available2020-05-20T08:39:05Z
dc.date.issued2006
dc.identifier.citationAdvanced Synthesis and Catalysis, 348(18), p. 2626-2632 (2006); doi:10.1002/adsc.200600274
dc.identifier.issn1615-4150
dc.identifier.urihttp://hdl.handle.net/10651/54882
dc.description.abstractEnantiomerically pure 4-(dimethylamino)-3-(1-hydroxyalkyl)pyridines and 4-(dimethylamino)-3-[hydroxyACHTUNGTRENNUNG(phenyl)methyl]pyridine have been pre-pared through efficient chemoenzymatic routes. Forthis purpose different lipases and oxidoreductaseshave been tested in the preparation of opticallyactive 4-chloro derivatives and baker´s yeast wasfound to be an excellent catalyst for the bioreduc-tions of the corresponding ketones. Their applica-tions as enantioselective nucleophilic catalysts havebeen studied, important catalytic properties were ob-served in the stereoselective construction of quater-nary centersspa
dc.description.sponsorshipWe thank Novo Nordisk Co. for the generous gift of theCAL-B (Novozyme 435) and Jlich Fine Chemicals for alco-hol dehydrogenases from Thermoanaerobacter species (T-ADH) and Lactobacillus brevis (LB-ADH). Financial sup-port of this work by the European Project EU-04-LSHB-2003–503017 is gratefully acknowledged. V.G.-F. thanksMEC for a personal grant (Juan de la Cierva Program). E.B.thanks MEC for a pre-doctoral fellowshipspa
dc.format.extentp. 2626-2632
dc.language.isoengspa
dc.relation.ispartofAdvanced Synthesis and Catalysis, 348spa
dc.rights© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
dc.titleEnantioselective Synthesis of 4-(Dimethylamino)pyridinesthrough a Chemical Oxidation-Enzymatic Reduction Sequence.Application in Asymmetric Catalysisspa
dc.typejournal articlespa
dc.identifier.doi10.1002/adsc.200600274
dc.relation.projectIDEU-04-LSHB-2003–503017spa
dc.relation.publisherversionhttps://doi.org/10.1002/adsc.200600274spa


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