Cytosolic copper is a major modulator of germination, development and secondary metabolism in Streptomyces coelicolor

We thank the European Research Council (ERC Starting Grant; Strp-diferentiation 280304) and the Spanish “Ministerio de Economía, Industria y Competitividad” (MINECO; BIO2015-65709-R and CTQ2016-80069-C2-1R) for fnancial support. Nathaly Gonzalez-Quiñonez was funded by a Severo Ochoa fellowship (FICYT, Consejería de Educación y Ciencia, Asturias, Spain). Roberto Álvarez-Fernández García was funded by “Fundación para la Investigación Biosanitaria de Asturias” (FINBA, Asturias, Spain). Tanks to Beatriz Gutierrez Magan (Universidad de Oviedo, Dpto. Biología Funcional, Área de Microbiología) for her laboratory assistance, Paul Dyson and Meirwyn Evans (Swansea University) for providing the disrupted cosmids, Wouter de Jong (University of Groningen, the Netherlands) for providing the S. coelicolor NepA mutant strain, Proof-ReadingService.com and Nature Publishing Group Language Editing service for proofreading the text.