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Disease liability prediction from large scale genotyping data using classifiers with a reject option
dc.contributor.author | Quevedo Pérez, José Ramón | |
dc.contributor.author | Bahamonde Rionda, Antonio | |
dc.contributor.author | Pérez Enciso, Miguel | |
dc.contributor.author | Luaces Rodríguez, Óscar | |
dc.date.accessioned | 2013-01-30T10:23:18Z | |
dc.date.available | 2013-01-30T10:23:18Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | IEEE/ACM Transactions on Computational Biology and Bioinformatics, 9(1), p. 88-97 (2012); doi:10.1109/TCBB.2011.44 | spa |
dc.identifier.issn | 1545-5963 | |
dc.identifier.uri | http://hdl.handle.net/10651/11223 | |
dc.description.abstract | Genome-wide association studies (GWA) try to identify the genetic polymorphisms associated with variation in phenotypes. However, the most significant genetic variants may have a small predictive power to forecast the future development of common diseases. We study the prediction of the risk of developing a disease given genome-wide genotypic data using classifiers with a reject option, which only make a prediction when they are sufficiently certain, but in doubtful situations may reject making a classification. To test the reliability of our proposal, we used the Wellcome Trust Case Control Consortium (WTCCC) data set, comprising 14,000 cases of 7 common human diseases and 3,000 shared controls | |
dc.format.extent | p. 88-97 | spa |
dc.language.iso | eng | |
dc.publisher | IEEE | |
dc.relation.ispartof | IEEE/ACM Transactions on Computational Biology and Bioinformatics, 9(1) | spa |
dc.rights | © IEEE | |
dc.subject | Genome-wide analysis | |
dc.subject | Classification with a reject option | |
dc.subject | Risk of common human diseases | |
dc.title | Disease liability prediction from large scale genotyping data using classifiers with a reject option | spa |
dc.type | journal article | |
dc.identifier.local | 20120016 | spa |
dc.identifier.doi | 10.1109/TCBB.2011.44 | |
dc.relation.publisherversion | http://dx.doi.org/10.1109/TCBB.2011.44 | |
dc.rights.accessRights | open access |
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