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Repositorio de la Universidad de Oviedo. > Producción Bibliográfica de UniOvi: RECOPILA > Artículos >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/6779

Title: Nanoparticles as fluorescent labels for optical imaging and sensing in genomics and proteomics
Author(s): Coto García, Ana María
Sotelo González, Emma
Fernández Fernández-Argüelles, María Teresa
Pereiro García, María Rosario
Costa Fernández, José Manuel
Sanz Medel, Alfredo
Keywords: Proteomics . Nanoparticle . Bioanalysis . Genomics . Imaging
Issue date: 2011
Publisher version: http://dx.doi.org/10.1007/s00216-010-4330-3
Citation: Analytical and Bioanalytical Chemistry, 399(1), p. 29-42 (2011); doi:10.1007/s00216-010-4330-3
Format extent: p. 29-42
Abstract: Optical labelling reagents (dyes and fluorophores) are an essential component of probe-based biomolecule detection, an approach widely employed in a variety of areas including environmental analysis, disease diagnostics, pharmaceutical screening, and proteomic and genomic studies. Recently, functional nanomaterials, as a new generation of high-value optical labels, have been applied to molecular detection. The great potential of such recent optical labels has paved the way for the development of new biomolecule assays with unprecedented analytical performance characteristics, related to sensitivity, multiplexing capability, sample throughput, cost-effectiveness and ease of use. This review aims to provide an overview of recent advances using different nanoparticles (such as quantum dots, rare earth doped nanoparticles or gold nanoparticles) for analytical genomics and proteomics, with particular emphasis on the outlook for different strategies of using nanoparticles for bioimaging and quantitative bioanalytical applications, as well as possibilities and limitations of nanoparticles in such a growing field.
URI: http://hdl.handle.net/10651/6779
ISSN: 1618-2642
Local identifier: 20110063
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