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Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/6547

Title: Human odontoblasts express transient receptor protein and acid-sensing ion channel mechanosensor proteins
Author(s): Sole Magdalena, Antonio
González Revuelta, Enrique
Menéndez Díaz, Iván
García Calavia, Marta
Cobo Díaz, Teresa
García Suárez, Olivia
Pérez Piñera, Pablo
Carlos Villafranca, Félix Antonio de
Cobo Plana, Juan Manuel
Vega Álvarez, José Antonio
Issue date: 2011
Publisher version: http://dx.doi.org/10.1002/jemt.20931
Citation: Microscopy research and technique, 74(5), p. 457-463 (2011); doi:10.1002/jemt.20931
Format extent: p. 457-463
Abstract: Diverse proteins of the denegerin/epithelial sodium channel (DEG/ENa+C) superfamily, in particular those belonging to the acid-sensing ion channel (ASIC) family, as well as some members of the transient receptor protein (TRP) channel, function as mechanosensors or may be required for mechanosensation in a diverse range of species and cell types. Therefore, we investigated the putative mechanosensitive function of human odontoblasts using immunohistochemistry to detect ENa+C subunits (α, β, and γ) and ASIC (1, 2, 3, and 4) proteins, as well as TRPV4, in these cells. Positive and specific immunoreactivity in the odontoblast soma and/or processes was detected for all proteins studied except α-ENa+C. The intensity of immunostaining was high for β-ENa+C and ASIC2, whereas it was low for ASIC1, ASIC3, γ-ENa+C, and TRPV4, being absent for α-ENa+C and ASIC4. These results suggest that human odontoblasts in situ express proteins related to mechanosensitive channels that probably participate in the mechanisms involved in teeth sensory transmission. Microsc. Res. Tech., 2011. © 2010 Wiley-Liss, Inc.
URI: http://hdl.handle.net/10651/6547
ISSN: 1059-910X
Local identifier: 20111955
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