TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance
Palabra(s) clave:
Cáncer de cabeza y cuello
Fecha de publicación:
Editorial:
MDPI
Versión del editor:
Citación:
Resumen:
Therapy resistance in head and neck squamous cell carcinoma (HNSCC) patients is the main obstacle to achieve more e ective treatments that improve survival and quality of life of these patients. Therefore, it is of vital importance to unravel the molecular and cellular mechanisms by which tumor cells acquire resistance to chemotherapy. We conducted a comparative proteomic study involving cisplatin-resistant cells and cancer stem cells with the aim of identifying proteins potentially implicated in the acquisition of cisplatin resistance. Through this study, we identified for the first time tetraspanin-1 (TSPAN1) as an important protein involved in the development, progression and chemoresistance of HNSCC tumors.
Therapy resistance in head and neck squamous cell carcinoma (HNSCC) patients is the main obstacle to achieve more e ective treatments that improve survival and quality of life of these patients. Therefore, it is of vital importance to unravel the molecular and cellular mechanisms by which tumor cells acquire resistance to chemotherapy. We conducted a comparative proteomic study involving cisplatin-resistant cells and cancer stem cells with the aim of identifying proteins potentially implicated in the acquisition of cisplatin resistance. Through this study, we identified for the first time tetraspanin-1 (TSPAN1) as an important protein involved in the development, progression and chemoresistance of HNSCC tumors.
Patrocinado por:
This work was supported by grants from the Instituto de Salud Carlos III (ISCIII): PI15/01262 (M.E.LL.) PI19/00560 (J.M.G.-P.) and CP03/00101 (M.E.L.), CIBERONC (CB16/12/00390 to J.P.R.), Ayudas a Grupos PCTI Principado de Asturias (IDI2018/155 to J.P.R.), co-financed by the European Regional Fund (ERDF) and AECC (Spanish Association of Cancer Research) Founding Ref. GC16173720CARR (M.E.L.). Y.G.-M. and C.M. were granted by the VHIR and iP-FIS (ISCIII) fellowships respectively.
Colecciones
- Artículos [35482]
- Cirugía y Especialidades Médico Quirúrgicas [288]
- Investigaciones y Documentos OpenAIRE [7762]