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Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/54885

Title: Enzymatic Preparation of Novel Aminoalkylpyridines usingLipases in Organic Solvents
Author(s): Torre González, Oliver
Busto García, Benjamín Eduardo
Gotor Fernández, Vicente
Gotor Santamaría, Vicente Miguel
Issue date: 2007
Publisher version: https://doi.org/10.1002/adsc.200600634
Citation: Advanced Synthesis and Catalysis, 349(8-9), p. 1481-1488 (2007); doi:10.1002/adsc.200600634
Format extent: p. 1481-1488
Abstract: A wide range of novel, enantiomericallypure 4-chloroACHTUNGTRENNUNG(amino)pyridine derivatives has beensynthesised through a chemoenzymatic approach,Candida antarctica lipase B (CAL-B) and Pseudomo-nas cepacia lipase (PSL) being found to be excellentbiocatalysts for the preparation of new and interest-ing amines and amides in enantiomerically pureform through enzymatic aminolysis reactions. Astudy of the enzymatic reactivity of CAL-B and PSLhas been done in the resolution of a library of aminestructures in an attempt to rationalise the experimen-tal results obtained in their enzymatic kinetic resolu-tion mediated by lipases
URI: http://hdl.handle.net/10651/54885
ISSN: 1615-4150
Sponsored: Financial support of this work by the European Project EU-04-LSHB-2003–503017 and the Principado de Asturias (IB-05–109) is gratefully acknowledged. V. G.-F. and E. B thankMinisterio de Educación y Ciencia for a personal grant (Juande la Cierva Program), and a pre-doctoral fellowship respec-tively.
Project id.: EU-04-LSHB-2003–503017
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