This work was partially financed by FIS/Spain grant numbers FIS-01/310, FIS-PI03/0365, and FIS PI06/0604. FICYT Asturias grant numbers FICYT PB02-67 and FICYT IB09-133 and grant 2015 from Fundacion Caja Rural de Asturias. We thank Fundacion Caja Rural de Asturias for financial collaborative support to Laboratorio de Oncologia Molecular (HUCA). The Instituto Universitario de Oncologia is supported by Fundacion Bancaria Caja de Ahorros de Asturias, Spain. We thank Biobanco del Principado de Asturias at HUCA for providing the samples for this study. We are also very grateful to the patients who have participated in this study.