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Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/43527

Title: Association of p21 Ser31Arg and p53 Arg72Pro polymorphisms with lung cancer risk in CAPUA study
Author(s): Souto García, Ana
Fernández Somoano, Ana
Pascual, Teresa
Álvarez Avellón, Sara María
Tardón García, Adonina
Keywords: Molecular epidemiology
Cell cycle
Tobacco
Oncology
Issue date: 2012
Publisher version: http://dx.doi.org/10.2147/LCTT.S35287
Citation: Lung Cancer: Targets and Therapy, 3, p. 69-78 (2012); doi:10.2147/LCTT.S35287
Format extent: p. 69-78
Abstract: Background: The aim of this study was to investigate how Ser31Arg polymorphisms in p21 may modify lung cancer susceptibility. Because p21 is the major downstream mediator of p53, we analyzed the combined effect of two polymorphisms, p21 Ser31Arg and TP53 Arg72Pro, to elucidate whether polymorphic variants determine the risk of lung cancer. Methods: This was designed as a hospital-based case-control study, and included 675 cases and 675 control subjects matched by ethnicity, gender, and age. Genotypes were determined by polymerase chain reaction restriction fragment length polymorphism, and multivariate unconditional logistic regression was performed to analyze the results. Results: Subjects who carried the p21 Ser31Arg allele had a higher risk of lung cancer (adjusted odds ratio [OR] 1.38; 95% confidence interval [CI] 0.99–2.03). This risk was increased in men aged younger than 55 years (adjusted OR 2.35; 95% CI 1.00–5.51). Smokers had an increased risk of lung cancer (adjusted OR 2.23; 95% CI 1.24–4.02). Men younger than 55 years carrying risk alleles for both genes (p21 Ser31Arg and TP53 Arg72Pro) had an increased risk (adjusted OR 5.78; 95% CI 1.38–24.19), as did smokers with both risk alleles (adjusted OR 4.52; 95% CI 1.52–13.50). Conclusion: The presence of both variant alleles increased the risk of developing lung cancer in men, particularly in smokers younger than 55 years
URI: http://hdl.handle.net/10651/43527
ISSN: 1179-2728
Sponsored: We would like to thank all the patients who participated in the study. We are also indebted to the Instituto Universitario de Oncología, which is supported by Obra Social Cajastur-Asturias, Spain. This work was supported by the Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología (BP09-031, IB09-133), Instituto de Salud Carlos III [FISS-PI060604], and Obra Social Cajastur
Project id.: BP09-031
IB09-133
FISS-PI060604
Appears in Collections:Medicina
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Investigaciones y Documentos OpenAIRE

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