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Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/43509

Title: Alcohol and lung cancer risk among never smokers: A pooledanalysis from the international lung cancer consortium and theSYNERGY study
Author(s): Fehringer, Gordon
Brenner, Darren R.
Zhang, Zuo-Feng
Lee, Y. A.
Matsuo, Keitaro
Ito, Hidemi
Lan, Qing
Fernández Somoano, Ana
Tardón García, Adonina
Keywords: Alcohol
Issue date: 2017
Publisher version: http://dx.doi.org/10.1002/ijc.30618
Citation: International Journal of Cancer, 140, p. 1976–1984 (2017); doi:10.1002/ijc.30618
Format extent: p. 1976–1984
Abstract: It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0-4.9 g per day: OR = 0.80, 95% CI = 0.70-0.90; 5-9.9 g per day: OR = 0.82, 95% CI = 0.69-0.99; 10-19.9 g per day: OR = 0.79, 95% CI = 0.65-0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance
URI: http://hdl.handle.net/10651/43509
ISSN: 0020-7136
Sponsored: Grant sponsor: Canadian Cancer Society; Grant number: CCSRI no. 020214; Grant sponsor: Ministry of Education, Science, Sports, Culture and Technology of Japan (AICHI: MEXT Kakenhi); Grant numbers: 170150181 and 26253041; Grant sponsor: European Commission’s INCO-COPERNICUS Program; Grant number: IC15-CT96-0313; Grant sponsor: National Institutes of Health; Grant numbers: NIH R01CA060691, NIH R01CA87895, NIH P30CA022453, NIH P30 CA008748, HHSN261201200011; Grant sponsor: National Cancer Institute; Grant numbers: CA092824, CA074386, CA090578; Grant sponsor: FIS-FEDER/Spain; Grant numbers: FIS-01/310, FISPI03-0365, and FIS-07-BI060604; Grant sponsor: FICYT/Asturias; Grant numbers: FICYT PB02-67, FICYT IB09-133; Grant sponsor: National Center for Research Resources; Grant number: P20RR018787; Grant sponsor: Research Intention PRVOUK; Grant number: PRVOUK P28/1LF/6; Grant sponsors: Intramural Research Program of the National Institutes of Health; Third Term Comprehensive 10-Year Strategy for Cancer Control from Ministry Health, Labour and Welfare of Japan; Steps for Breath, the Labrecque Foundation and the Society of Memorial Sloan-Kettering Cancer Center; The University of Oviedo, Asturias, Spain; The Fundacion Caja de Ahorros de Asturias and the Ciber de Epidemiologia y Salud Publica, CIBERESP, Spain; Baden-Wurttemberg State Ministry of Research, Science and Arts; Danish Cancer Society
Project id.: INCO-COPERNICUS/IC15-CT96-0313
FICYT IB09-133
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