Y.M. is supported by a Ficyt (Gobierno del Principado de Asturias, Spain) fellowship and T.F. is supported by the IUOPA. The present study is partially supported by a grant from European Union FEDER funds, Principado de Asturias (Plan de Ciencia, Tecnologia e Innovacion), FICYT (GRUPIN 14-069), to J.A.V., S.C. and A.J.O, and by a grant from the Fondo de Investigaciones Sanitarias, FISS PI11/00371. IUOPA is supported by the Obra Social Cajastur, Asturias, Spain.