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Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/33649

Title: New insights on the development of Streptomyces and their relationships with secondary metabolite production
Author(s): Yagüe Menéndez, Paula
López García, María Teresa (Bio)
Rioseras de Bustos, Beatriz
Sánchez Martín, Jesús
Manteca Fernández, Ángel
Keywords: Streptomyces
Differentiation
sporulation
Antibiotic
Issue date: 2012
Publisher: Research Trends
Citation: Current trends in microbiology, 8, p. 65-73 (2012)
Format extent: p. 65-73
Abstract: Streptomycetes are very important industrial bacteria, which produce two thirds of all clinically relevant secondary metabolites. Furthermore, they produce large numbers of eukaryotic cell differentiation and apoptosis inducers. Streptomyces is a mycelial soil bacterium characterized by a complex developmental cycle that includes programmed cell death (PCD) phenomena and sporulation in solid cultures. Industrial fermentations are usually performed in liquid cultures, conditions in which Streptomyces strains generally do not sporulate, and it was traditionally assumed that there was no differentiation. Recently, novel aspects concerning differentiation during the presporulation phases were described in solid and liquid cultures, as well as in natural soils. In this review, we analyze the status of knowledge regarding the above-named aspects of Streptomyces differentiation and their relationships with secondary metabolite production.
URI: http://hdl.handle.net/10651/33649
ISSN: 0972-7736
Sponsored: Authors wish to thank the European Research Council for economic support (ERC Starting Grant; Strpdifferentiation 280304) and Subdirección General de Proyectos de Investigación (DGI MICINN, Spain, grant BIO2010-16303).
Project id.: Strp-differentiation 280304
MICINN/BIO/2010-16303
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