This work was supported by grants from the Ministerio de Economıa y Competitividad, Instituto de Salud Carlos III (RTICC), and Red Tematica de Investigacion Cooperativa en Enfermedades Cardiovasculares. The Instituto Universitario de Oncologıa is supported by Obra Social Cajastur. K.W. is supported by the Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation from Japan Society for the Promotion of Science. C.L-O. is an investigator for the Botin Foundation.