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Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/28924

Title: Isolation and characterization of Schizosaccharomyces pombe mutants lacking aminopeptidase activity
Author(s): Arbesú, María José
Gascón Muñoz, Santiago
Suárez Rendueles, María Paz
Issue date: 1991
Publisher: Wiley
Publisher version: http://dx.doi.org/10.1002/yea.320070512
Citation: Yeast, 7(5), p. 525–531 (1991); doi:10.1002/yea.320070512
Format extent: p. 525-531
Abstract: A mutant strain of the fission yeast Schizosaccharomyces pombe defective in aminopeptidase I was isolated by screening for lack of activity against the chromogenic substrate lysine-β-naphthlamide in isolated colonies. Tetrad dissection of sporulated diploids heterozygous for the wild-type and mutant allele resulted in a 2:2 segregation of mutant and wild-type phenotype indicating a single chromosomal gene mutation. Gene dosage experiments indicated that the mutation might reside in the structural gene of aminopeptidase I. No vital consequences of aminopeptidase I deficiency on cell life and sporulation could be detected. However, the enzyme seems to be involved in protein degradation under conditions of nutrient deprivation
URI: http://hdl.handle.net/10651/28924
ISSN: 0749-503X
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