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Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/10676

Title: The potential of mass spectrometry to study iron-containing proteins used in clinical diagnosis
Author(s): Castillo Busto, María Estela del
Montes Bayón, María
Sanz Medel, Alfredo
Keywords: Ion; Iron-Proteins; Mass Spectrometry; Clinical Diagnosis
Issue date: 2009
Publisher version: http://dx.doi.org/10.1016/j.aca.2008.12.014
Citation: Analytica Chimica Acta, 634(1), p. 1-14 (2009); doi:10.1016/j.aca.2008.12.014
Format extent: p. 1-14
Abstract: Many proteins contain iron as metal ion either within their own structures or bound to their active sites. These iron-containing proteins are involved in numerous biological processes and some of them serve as biomarkers of clinical pathologies, not only related to iron homeostasis but also to other physiological disorders. Thus, a variety of analytical strategies have been developed over the last years in order to conduct studies on Fe-containing proteins. Among them, mass spectrometric (MS) methods still remain as preferred tools since they provide the capabilities of structure elucidation together with quantitative possibilities. Therefore, in this work we have tried to summarize the most recent applications of elemental and molecular mass spectrometric-based methods for the characterization (mostly qualitative but quantitative in some cases) of the high abundant Fe-containing proteins used for clinical diagnosis.
URI: http://hdl.handle.net/10651/10676
ISSN: 0003-2670
Local identifier: 20090792
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