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Please use this identifier to cite or link to this item: http://hdl.handle.net/10651/10148

Title: Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents
Author(s): Alvarado Narváez, Mario
Goya Laza, Pilar
Macías González, Manuel
Pavón, Francisco Javier
Serrano, Antonia
Jagerovic, Nadine
Elguero Bertolini, José
Gutiérrez Rodríguez, Ángel
García-Granda, Santiago
Suardíaz, Margarita
Rodríguez de Fonseca, Fernando
Keywords: Pyrazole; Oleylamide; Pparα; Dmls
Issue date: 2008
Publisher version: http://dx.doi.org/10.1016/j.bmc.2008.10.023
Citation: Bioorganic & Medicinal Chemistry, 16(23), P. 10098-10105 (2008); doi:10.1016/j.bmc.2008.10.023
Format extent: p. 10098-10105
Abstract: Searching for new antiobesity agents, a new series of fatty acid amide derivatives of 1,5-diarylpyrazole have been synthesized as dual peroxisome proliferator activated receptor alpha (PPARα)/cannabinoid receptor ligands. The compounds have been evaluated in vivo and in vitro as PPARα activators and as cannabinoids in two tests of the mouse tetrad. In vivo, food intake studies have been performed with all the compounds. No significant cannabinoid activity has been found but some compounds behaved as potent PPARα activators. Several compounds showed anorexigenic properties reducing food intake in rats.
URI: http://hdl.handle.net/10651/10148
ISSN: 0968-0896
Local identifier: 450
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