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Showing results 1 to 20 of 23
Issue DateTitleAuthor(s)
2014The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcriptionFernández Guizán, Azahara; Mansilla Barrado, Sylvia; Barceló, Francisca; Vizcaíno, Carolina; Núñez González, Luz Elena; Morís Varas, Francisco; González Rodríguez, Segundo; Portugal Minguela, José
30-Jun-2004Aislamiento y caracterización de los genes implicados en la biosíntesis del antibiótico b-lactámico tienamicina en streptomyces cattleyaNúñez González, Luz Elena
2015Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancerCuenca López, María D.; Serrano Heras, Gemma; Montero, Juan Carlos; Corrales Sánchez, Verónica; Gómez Juárez, Mónica; Gascón Escribano, María José; Morales, Jorge Carlos; Voisin, Veronique; Núñez González, Luz Elena; Morís Varas, Francisco; Bader, Gary D.; Pandiella, Atanasio; Ocaña, Alberto
2015Antitumoral activity of the mithralog EC-8042 in triple negative breast cancer linked to cell cycle arrest in G2Pandiella, Atanasio; Morís Varas, Francisco; Ocaña, Alberto; Núñez González, Luz Elena; Montero, Juan Carlos
2003The biosynthetic gene cluster for the β-lactam carbapenem thienamycin in Streptomyces cattleyaNúñez González, Luz Elena; Méndez Fernández, María del Carmen; Fernández Braña, Alfredo Javier; Blanco Blanco, María Gloria; Salas Fernández, José Antonio
2011The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycinGarcía Fernández, Beatriz; González Sabín, Javier; Menéndez Sánchez, Nuria; Fernández Braña, Alfredo Javier; Núñez González, Luz Elena; Morís Varas, Francisco; Salas Fernández, José Antonio; Méndez Fernández, María del Carmen
26-Feb-2004Gene cluster for thienamycin biosynthesis, genetic manipulation and utilityNúñez González, Luz Elena; Blanco Blanco, María Gloria; Fernández Braña, Alfredo Javier; Méndez Fernández, María del Carmen; Salas Fernández, José Antonio
2014Genome-wide modulation of gene transcription in ovarian carcinoma cells by a new mithramycin analogueVizcaíno, Carolina; Núñez González, Luz Elena; Morís Varas, Francisco; Portugal Minguela, José
2016High-quality draft genome sequence of the actinobacterium Nocardia terpenica IFM 0406, producer of the immunosuppressant brasilicardins, using illumina and PacBio technologiesBuchmann, Anina; Eitel, Michael; Koch, Pierre; Schwarz, Paul N.; Stegmann, Evi; Wohlleben, Wolfgang; Wolanski, Marcin; Krawiec, Michal; Zakrzewska Czerwinska, Jolanta; Méndez Fernández, María del Carmen; Botas Muñoz, Alma María; Núñez González, Luz Elena; Morís Varas, Francisco; Fernández Cortés, Jesús; Gross, Harald S.
2016Identification of mithramycin analogues with improved targeting of the EWS-FLI1 transcription factorOsgood, Christy L.; Maloney, Nichole K.; Kidd, Christopher G.; Kitchen Goosen, Susan M.; Segars, Laure E.; Gebregiorgis, Meti; Woldemichael, Girma Moges; He, Min; Sankar, Savita; Lessnick, Stephen L.; Kang, Min; Smith, Malcolm A.; Turner, Lisa; Madaj, Zachary B.; Winn, Mary E.; Núñez González, Luz Elena; González Sabín, Javier; Helman, Lee J. R. F.; Morís Varas, Francisco; Grohar, Patrick J.
2008Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleyaRodríguez García, Miriam; Núñez González, Luz Elena; Fernández Braña, Alfredo Javier; Méndez Fernández, María del Carmen; Salas Fernández, José Antonio; Blanco Blanco, María Gloria
2018Inhibition of FLT3 and PIM Kinases by EC-70124 Exerts Potent Activity in Preclinical Models of Acute Myeloid LeukemiaPuente Moncada, Noelia; Costales, Paula; Antolín González, Isaac; Núñez González, Luz Elena; Oro Carbajosa, Patricia; Hermosilla Olarte, Ana María; Ríos Lombardía, Nicolás; Sánchez Sánchez, Ana María; Luño Fernández, Elisa; Martín Fernández, Vanesa
2016Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcomaTornin Cavielles, Juan; Martínez Cruzado, Lucía; Santos Duque, Laura; Rodríguez García, Aida; Núñez González, Luz Elena; Oro Carbajosa, Patricia; Allonca Campa, Eva; Astudillo González, María Aurora; Suárez Nieto, Carlos; Rodríguez González, René
2010Involvement of the Beta Subunit of RNA Polymerase in Resistance to Streptolydigin and Streptovaricin in the Producer Organisms Streptomyces lydicus and Streptomyces spectabilisSánchez Hidalgo, Marina; Núñez González, Luz Elena; Méndez Fernández, María del Carmen; Salas Fernández, José Antonio
2012Lipase-catalyzed preparation of chromomycin A3 analogues and biological evaluation for anticancer activityGonzález Sabín, Javier; Núñez González, Luz Elena; Menéndez Sánchez, Nuria; Fernández Braña, Alfredo Javier; Méndez Fernández, María del Carmen; Salas Fernández, José Antonio; Gotor Santamaría, Vicente Miguel; Morís Varas, Francisco
2012Modulation of the activity of sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancerMalek, A.; Núñez González, Luz Elena; Magistri, M.; Brambilla, L.; Jovic, S.; Carbone, G. M.; Morís Varas, Francisco; Catapano, C. V.
2011Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleyaRodríguez García, Miriam; Núñez González, Luz Elena; Fernández Braña, Alfredo Javier; Méndez Fernández, María del Carmen; Salas Fernández, José Antonio; Blanco Blanco, María Gloria
2012A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesisNúñez González, Luz Elena; Nybo, Stephen E.; González Sabín, Javier; Pérez, María; Fernández Braña, Alfredo Javier; Salas Fernández, José Antonio; Méndez Fernández, María del Carmen
2012Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genesVizcaíno, Carolina; Mansilla Barrado, Sylvia; Núñez González, Luz Elena; Méndez Fernández, María del Carmen; Salas Fernández, José Antonio; Morís Varas, Francisco; Portugal Minguela, José
2015Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitorsSerrano Heras, Gemma; Cuenca López, María Dolores; Montero, Juan Carlos; Corrales Sánchez, Verónica; Morales, Jorge Carlos; Núñez González, Luz Elena; Morís Varas, Francisco; Pandiella, Atanasio; Ocaña, Alberto
Showing results 1 to 20 of 23

 

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